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Sci. Signal., 21 October 2008
[DOI: 10.1126/scisignal.2000008]

Supplementary Materials for
Fault Diagnosis Engineering of Digital Circuits Can Identify Vulnerable Molecules in Complex Cellular Pathways

Ali Abdi,1 Mehdi Baradaran Tahoori,2 and Effat S. Emamian3*†

1Center for Wireless Communications and Signal Processing Research, Department of Electrical and Computer Engineering, New Jersey Institute of Technology, 323 King Boulevard, Newark, NJ 07102, USA.

2Department of Electrical and Computer Engineering, Northeastern University, 307 Dana Research Building, Boston, MA 02115, USA.

3Advanced Technologies for Novel Therapeutics (ATNT), 211 Warren Street, Newark, NJ 07103, USA.

Work initiated at The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

This PDF file includes:

  • Methods
  • Fig. S1. Intermolecular interactions of the p53 network.
  • Fig. S2. The digital electronic p53 circuit.
  • Fig. S3. Intermolecular interactions of the CREB network.
  • Fig. S4. The digital electronic CREB circuit.
  • Fig. S5. A typical path between an erroneous node to primary outputs and flipflops.
  • Fig. S6. A simple path between an erroneous input to a primary output.
  • Fig. S7. Applying error propagation rules for a reconverging path.
  • Table S1. Logic equations of the caspase3–FKHR network.
  • Table S2. Logic equations of the p53 network.
  • Table S3. Logic equations of the CREB network.
  • Table S4. Computing probability at the output of a gate in terms of its inputs.
  • References

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Technical Details

Format: Adobe Acrobat PDF

Size: 2771 KB

*To whom correspondence should be addressed. E-mail: emame{at}

Citation: A. Abdi, M. B. Tahoori, E. S. Emamian, Fault Diagnosis Engineering of Digital Circuits Can Identify Vulnerable Molecules in Complex Cellular Pathways. Sci. Signal. 1, ra10 (2008).

© 2008 American Association for the Advancement of Science

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