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Sci. Signal., 25 November 2008
[DOI: 10.1126/scisignal.1164263]

Supplementary Materials for
{gamma}-Secretase Limits the Inflammatory Response Through the Processing of LRP1

Kai Zurhove1,2, Chikako Nakajima1,2, Joachim Herz2,3, Hans H. Bock1,2, and Petra May1,2*

1Department of Medicine II, University Hospital and University of Freiburg, 79106 Freiburg, Germany.
2Centre of Neurosciences, University Hospital and University of Freiburg, 79104 Freiburg, Germany.
3Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. Quantification of Western blots.
  • Fig. S2. Detection of LRP1-ECD in transfected LRP1-deficient fibroblasts.
  • Fig. S3. Schematic representation of the LRP1-ECD mutant transfected into LRP1-deficient fibroblasts.
  • Fig. S4. Effect of dominant-negative presenilin on the processing of LRP1.
  • Fig. S5. Time course of DAPT treatment.
  • Fig. S6. Effect of purified rLPS on the processing of LRP1.
  • Fig. S7. Analysis of fusion proteins.
  • Fig. S8. Analysis of macrophages from wild-type and conditional LRP1–/– mice.
  • Table S1. Effects of LRP1 deficiency on target gene expression.
  • Table S2. Differential gene expression in wild-type and LRP1-deficient fibroblasts.
  • References

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Technical Details

Format: Adobe Acrobat PDF

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*To whom correspondence should be addressed. E-mail: Petra.May{at}

Citation: K. Zurhove, C. Nakajima, J. Herz, H. H. Bock, P. May, {gamma}-Secretase Limits the Inflammatory Response Through the Processing of LRP1. Sci. Signal. 1, ra15 (2008).

© 2008 American Association for the Advancement of Science

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