Supplementary Materials for
-Secretase Limits the Inflammatory Response Through the Processing of LRP1

Kai Zurhove^1,2, Chikako Nakajima^1,2, Joachim Herz^2,3, Hans H. Bock^1,2, and Petra May^1,2*

¹Department of Medicine II, University Hospital and University of Freiburg, 79106 Freiburg, Germany.
²Centre of Neurosciences, University Hospital and University of Freiburg, 79104 Freiburg, Germany.
³Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

This PDF file includes:

• Supplementary Materials and Methods
• Fig. S1. Quantification of Western blots.
• Fig. S2. Detection of LRP1-ECD in transfected LRP1-deficient fibroblasts.
• Fig. S3. Schematic representation of the LRP1-ECD mutant transfected into LRP1-deficient fibroblasts.
• Fig. S4. Effect of dominant-negative presenilin on the processing of LRP1.
• Fig. S5. Time course of DAPT treatment.
• Fig. S6. Effect of purified rLPS on the processing of LRP1.
• Fig. S7. Analysis of fusion proteins.
• Fig. S8. Analysis of macrophages from wild-type and conditional LRP1^–/– mice.
• Table S1. Effects of LRP1 deficiency on target gene expression.
• Table S2. Differential gene expression in wild-type and LRP1-deficient fibroblasts.
• References

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 452 KB

^*To whom correspondence should be addressed. E-mail: Petra.May{at}zfn.uni-freiburg.de

Citation: K. Zurhove, C. Nakajima, J. Herz, H. H. Bock, P. May, -Secretase Limits the Inflammatory Response Through the Processing of LRP1. Sci. Signal. 1, ra15 (2008).

© 2008 American Association for the Advancement of Science