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Sci. Signal., 3 March 2009
[DOI: 10.1126/scisignal.2000016]

Supplementary Materials for:

Odor Coding by a Mammalian Receptor Repertoire

Harumi Saito, Qiuyi Chi, Hanyi Zhuang, Hiro Matsunami,* and Joel D. Mainland*

*To whom correspondence should be addressed. E-mail: joel.mainland{at}gmail.com (J.D.M.) and hiroaki.matsunami{at}duke.edu (H.M.)

This PDF file includes:

  • Fig. S1. Dose-response curves of all 340 odorant/receptor interactions showing significant receptor activation.
  • Fig. S2. Odorant clustering based on receptor response.
  • Fig. S3. Receptor clustering based on response to odorants.
  • Fig. S4. Outline of the screening procedure.
  • Fig. S5. A phylogenetic tree of all 464 receptors in the screening library, as well as 1425 intact mouse and human ORs.
  • Fig. S6. Sensitivity-ordered tuning curves.
  • Fig. S7. One-dimensional tuning curves.
  • Fig. S8. Two-dimensional tuning plots.
  • Fig. S9. Snake plot comparison of ligand-specificity-determining residues.
  • Fig. S10. EC50 values for 62 odorant receptors and 63 odorants.
  • Table S2. Odorants used to screen the receptor libraries.
  • Table S3. The numerical EC50 values (log M) displayed in Fig. 1.
  • Table S4. CAS registry numbers for 2683 odorants used to estimate the size of odorant space.
  • Table S5. Sixteen amino acid property descriptors that explain more than 53% of the variance in our data set.

[Download PDF]

Updated 4 May 2009

There was an error in the code that generated the original Figure S10. A version of the Supplementary Materials with the correct Figure S10 is available.

[Download Corrected PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 9,422 KB (Original PDF)

Size: 9,222 KB (Corrected PDF)

Other Supplementary Material for this manuscript includes the following:

  • Table S1. Multiple alignment of all 464 receptors in the screening library, as well as 1425 intact mouse and human ORs (PDF and FAS format).
  • Table S3. The numerical EC50 values (log M) displayed in Fig. 1 (Microsoft Excel format).

[Download .ZIP]

Technical Details

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Size: 664 KB


Citation: H. Saito, Q. Chi, H. Zhuang, H. Matsunami, J. D. Mainland, Odor Coding by a Mammalian Receptor Repertoire. Sci. Signal. 2, ra9 (2009).

© 2009 American Association for the Advancement of Science


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