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Sci. Signal., 26 May 2009
[DOI: 10.1126/scisignal.2000230]

Supplementary Materials for:

Bruton's Tyrosine Kinase Revealed as a Negative Regulator of Wnt–β-Catenin Signaling

Richard G. James, Travis L. Biechele, William H. Conrad, Nathan D. Camp, Daniel M. Fass, Michael B. Major, Karen Sommer, XianHua Yi, Brian S. Roberts, Michele A. Cleary, William T. Arthur, Michael MacCoss, David J. Rawlings, Stephen J. Haggarty, Randall T. Moon*

*To whom correspondence should be addressed. E-mail: rtmoon{at}

This PDF file includes:

  • Fig. S1. Bioinformatic overlap of independent small-molecule and siRNA screens reveals previously unidentified regulators of Wnt–β-catenin signaling.
  • Fig. S2. Zebrafish expression and loss-of-function data.
  • Fig. S3. Protein interaction networks for BTK and CDC73.
  • Fig. S4. Context-dependent regulation of Wnt–β-catenin signaling by CDC73.
  • Table S1. Sequences of siRNA sense strands.
  • Table S2. Descriptions of supplementary database files.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 2.05 MB

Other Supplementary Material for this manuscript includes the following:

  • Databases S1 to S12, S16 to S18 (Microsoft Excel format)
  • Databases S13 to S15 (Cytoscape format)

[Download ZIP]

Technical Details

Format: Microsoft Excel and Cytoscape [compressed]

Size: 1.6 MB

Citation: R. G. James, T. L. Biechele, W. H. Conrad, N. D. Camp, D. M. Fass, M. B. Major, K. Sommer, X. Yi, B. S. Roberts, M. A. Cleary, W. T. Arthur, M. MacCoss, D. J. Rawlings, S. J. Haggarty, R. T. Moon, Bruton’s tyrosine kinase revealed as a negative regulator of Wnt–β-catenin signaling. Sci. Signal. 2, ra25 (2009).

© 2009 American Association for the Advancement of Science

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