Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases

Chris Soon Heng Tan, Bernd Bodenmiller, Adrian Pasculescu, Marko Jovanovic, Michael O. Hengartner, Claus Jørgensen, Gary D. Bader, Ruedi Aebersold, Tony Pawson, Rune Linding*

*To whom correspondence should be addressed. E-mail: linding{at}icr.ac.uk

This PDF file includes:

• Methods
• Fig. S1. Clustering analysis of core phosphorylation sites.
• Fig. S2. Phosphorylatable residues in disordered regions are fast evolving.
• Fig. S3. Phosphorylation site disorder analysis.
• Fig. S4. Schematic diagram of how the conserved phosphorylation propensity k of each human substrate is computed.
• Fig. S5. Box plot of number of human substrate relations observed as conserved in target species from randomized trials.
• Fig. S6. Core sites observed in activation loops of protein kinases.
• Table S1. Statistical significance of core sites observed between human and yeast.
• Table S2. Statistical significance of core sites observed between human and fly.
• Table S3. Statistical significance of core sites observed between human and worm.
• Table S4. Core sites identified in components of the β-catenin destruction complex.
• Table S5. Core sites identified in components of the clathrin coat of coated pits.
• Table S6. Core site identified in 22 cancer-associated genes.
• Table S7. Correlation of cancer-associated genes with conserved phosphorylation propensity k computed for individual target species.
• Table S8. Correlation of OMIM genes with conserved phosphorylation propensity k computed for individual target species.
• References
• Supplementary Data File Descriptions

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Other Supplementary Materials for this manuscript include the following:

Supplementary Data (ZIP file containing files in cys, tsv, txt, csv, and fa formats)

• 2000316Tan_SupplementalData.zip (file size 17.3 MB)

Citation: C. S. H. Tan, B. Bodenmiller, A. Pasculescu, M. Jovanovic, M. O. Hengartner, C. Jørgensen, G. D. Bader, R. Aebersold, T. Pawson, R. Linding, Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases. Sci. Signal. 2, ra39 (2009).

© 2009 American Association for the Advancement of Science