Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

Kai Yasukawa, Hiroyuki Oshiumi, Makoto Takeda, Naotada Ishihara, Yusuke Yanagi, Tsukasa Seya, Shun-ichiro Kawabata, Takumi Koshiba*

*To whom correspondence should be addressed. E-mail: koshiba{at}kyudai.jp

This PDF file includes:

• Materials
• Fig. S1. Interaction between endogenous mMfn2 and mMAVS in MEFs.
• Fig. S2. Knockdown of Mfn2 with specific siRNA results in enhanced MAVS-mediated activation of the IFN-β reporter.
• Fig. S3. Treatment of HEK 293 cells with Mfn2-specific siRNA increased the production of endogenous IFN-β in response to transfection with poly(I:C).
• Fig. S4. Mfn2-HR1 is a dominant-negative modulator of MAVS-mediated activation of NF-κB.
• Fig. S5. Sequence alignment of Mfn2 homologs within HR1.
• Table S1. List of mitochondrial proteins, other than Mfn2, that were identified by LC/MS/MS.
• Reference

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Citation: K. Yasukawa, H. Oshiumi, M. Takeda, N. Ishihara, Y. Yanagi, T.Seya, S.-i. Kawabata, T. Koshiba, Mitofusin 2 inhibits mitochondrial antiviral signaling. Sci. Signal. 2, ra47 (2009).

© 2009 American Association for the Advancement of Science