Hippo Pathway–Dependent and –Independent Roles of RASSF6

Mitsunobu Ikeda, Akira Kawata, Misa Nishikawa, Yuko Tateishi, Masato Yamaguchi, Kentaro Nakagawa, Susumu Hirabayashi, Yijun Bao, Shiho Hidaka, Yukio Hirata, Yutaka Hata*

*To whom correspondence should be addressed. E-mail: yuhammch{at}tmd.ac.jp

This PDF file includes:

• Fig. S1. Interaction of RASSF6 with MST2.
• Fig. S2. Molecular determinants of the interaction of MST2 with RASSF6 and WW45.
• Fig. S3. OA treatment induces apoptosis in rat hepatocytes.
• Fig. S4. The effect of the expression of various MST2 and WW45 proteins.
• Fig. S5. MST1 inhibits RASSF6-induced apoptosis, whereas RASSF6 inhibits the phosphorylation of MOB1 by MST1.
• Fig. S6. RASSF6-induced apoptosis is independent of the interaction with MST2 and NDR kinases.
• Fig. S7. Interaction of MOAP1 with RASSF6 and dRASSF.
• Fig. S8. dRASSF interacts with and inhibits MST2.
• Fig. S9. dRASSF or RASSF6 does not induce apoptosis in S2 cells.
• Table S1. Twenty-one–nucleotide oligomers used in this study.
• Table S2. Primers for quantitative RT-PCR.

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Citation: M. Ikeda, A. Kawata, M. Nishikawa, Y. Tateishi, M. Yamaguchi, K. Nakagawa, S. Hirabayashi, Y. Bao, S. Hidaka, Y. Hirata, Y. Hata, Hippo Pathway–Dependent and –Independent Roles of RASSF6. Sci. Signal. 2, ra59 (2009).

© 2009 American Association for the Advancement of Science