Sci. STKE, 22 April 2003
A Series on Protein Domains in Signal Transduction
16 December 2003
- Finding Partners: Emerging Protein Interaction Technologies Applied to Signaling Networks
SILAC, TAIS, domain profiling, and mbYTH are new methods for revealing protein partners.
[Summary] [Full Text] [PDF]
18 November 2003
- Organization and Functions of Interacting Domains for Signaling by Protein-Protein Interactions
Elizabeth Buck and Ravi Iyengar
Division of labor in protein interaction domains appears to separate binding from actual signal transfer. [Gloss] [Abstract] [Full Text] [PDF]
15 July 2003
- SH2 and PTB Domains in Tyrosine Kinase Signaling
Joseph Schlessinger and Mark A. Lemmon
Motifs that recognize phosphorylated tyrosines are essential regulators of cellular signaling events. [Gloss] [Abstract] [Full Text] [PDF]
- A Kelch b-Propeller Featuring as a Gb Structural Mimic: Reinventing the Wheel?
Jan Gettemans, Kris Meerschaert, Joël Vandekerckhove, and Veerle De Corte
Structural similarity may allow proteins with diverse primary sequences to serve in the G protein heterotrimer. [Summary] [Full Text] [PDF]
- Activation of Ras by Grb2-SOS: Demonstrating an Assembly Role of SH3 Domains
Ali Zarrinpar, Roby P. Bhattacharyya, Wendell A. Lim, and Nancy R. Gough
A simple animation showing how SH3 domains participate in mitogen-activated protein kinase signaling.
22 April 2003
- Gene Regulation at the RNA Layer: RNA-Binding Proteins in Intercellular Signaling Networks
How extracellular signals can regulate RNA processing, transport, and translation to control gene expression. [Gloss] [Abstract] [Full Text] [PDF]
- PDZ Domain Proteins: Plug and Play!
Claire Nourry, Seth G. N. Grant, and Jean-Paul Borg
PDZ domains provide the scaffold for functional complexes implicated in health and disease in polar cells. [Gloss] [Abstract] [Full Text] [PDF]
- The Structure and Function of Proline Recognition Domains
Ali Zarrinpar, Roby P. Bhattacharyya, and Wendell A. Lim
Understanding the structural basis of a commonly used motif present in many proteins involved in signal transduction.[Gloss] [Abstract] [Full Text] [PDF] [Structures]