A Series on Protein Domains in Signal Transduction

18 November 2003

• Organization and Functions of Interacting Domains for Signaling by Protein-Protein Interactions
  Elizabeth Buck and Ravi Iyengar
  Division of labor in protein interaction domains appears to separate binding from actual signal transfer. [Gloss] [Abstract] [Full Text] [PDF]

15 July 2003

• SH2 and PTB Domains in Tyrosine Kinase Signaling
  Joseph Schlessinger and Mark A. Lemmon
  Motifs that recognize phosphorylated tyrosines are essential regulators of cellular signaling events. [Gloss] [Abstract] [Full Text] [PDF]

• A Kelch b-Propeller Featuring as a Gb Structural Mimic: Reinventing the Wheel?
  Jan Gettemans, Kris Meerschaert, Joël Vandekerckhove, and Veerle De Corte
  Structural similarity may allow proteins with diverse primary sequences to serve in the G protein heterotrimer. [Summary] [Full Text] [PDF]

• Activation of Ras by Grb2-SOS: Demonstrating an Assembly Role of SH3 Domains
  Ali Zarrinpar, Roby P. Bhattacharyya, Wendell A. Lim, and Nancy R. Gough
  A simple animation showing how SH3 domains participate in mitogen-activated protein kinase signaling. [Summary] [Resource]

22 April 2003

• Gene Regulation at the RNA Layer: RNA-Binding Proteins in Intercellular Signaling Networks
  Paul Lasko
  How extracellular signals can regulate RNA processing, transport, and translation to control gene expression. [Gloss] [Abstract] [Full Text] [PDF]
• PDZ Domain Proteins: Plug and Play!
  Claire Nourry, Seth G. N. Grant, and Jean-Paul Borg
  PDZ domains provide the scaffold for functional complexes implicated in health and disease in polar cells. [Gloss] [Abstract] [Full Text] [PDF]
• The Structure and Function of Proline Recognition Domains
  Ali Zarrinpar, Roby P. Bhattacharyya, and Wendell A. Lim
  Understanding the structural basis of a commonly used motif present in many proteins involved in signal transduction.[Gloss] [Abstract] [Full Text] [PDF] [Structures]