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Sci. STKE, 10 February 2004
[DOI: 10.1126/stke.2192004pl4]

Developing Complex Signaling Models Using GENESIS/Kinetikit
(Software and Demos)

Sharat Jacob Vayttaden* and Upinder Singh Bhalla*

National Centre for Biological Sciences, Tata Institute of Fundamental Research, GKVK Campus, Bangalore 560065, India.

*Corresponding authors. Telephone, +91-80-2363-6420; fax, +91-80-2363-6662; E-mail: sharat{at}; bhalla{at}

Software and Demos. GENESIS/Kinetikit, a graphical simulation environment. The downloadable materials include computer modeling software called GEneral NEural SImulation System (GENESIS)/Kinetikit, a graphical simulation environment and examples relevant to cellular signaling from an associated library of models available at the Database of Quantitative Cellular Signaling (DOQCS), which together are designed to facilitate modeling of signaling networks. The demonstration simulations provided may also have some teaching value in exploring the properties of signaling circuits. The software is also available from a mirror site ( and additional models can be downloaded from DOQCS (

[Download Software]

Technical Details

Format: GENESIS/Kinetikit software

Size: ~1.2 MB download and 4 MB uncompressed

Requirements: The software requires a PC with Linux operating system (Kernel 2.4 or later, for example, Red Hat Linux 7.2 and higher)


Citation: S. J. Vayttaden, U. S. Bhalla, Developing complex signaling models using GENESIS/Kinetikit. Sci. STKE 2004, pl4 (2004).

© 2004 American Association for the Advancement of Science

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