| Section and lecture title |
Brief content and organizational comments |
| Part 1: Principles of Cell Signaling Systems |
A different lecturer may present each topic, and a single person should be selected as the coordinator for this section. |
| General Introduction and Introduction to G Protein-Coupled Receptor (GPCR) Signaling |
Principles underlying cell communication with a focus on heterotrimeric G protein pathways |
| Growth Factor/Receptor Tyrosine Kinases (RTKs) and Wnt Receptors |
Initiation of signaling through classical growth factor receptors and Wnt pathways |
| Ras to Mitogen-Activated Protein Kinase (MAPK) Pathways |
Classical signaling pathways to MAPKs |
| Protein Kinases |
Structure-function relationships and regulation of protein functions through phosphorylation |
| Protein Phosphatases |
Structure/function relationships and regulation of protein function by phosphatases |
| Domains in RTKs: Structural Aspects |
Protein domains in signaling: SH2, PTB domains |
| Discussion Forum |
All lecturers in this section may participate in this class, or a single lecturer may guide the discussion. |
| Part 2: G Protein Signaling |
A different lecturer may present each topic, and a single person should be selected as the coordinator for this section. |
| Structure of GPCRs, G proteins, and GTPases |
Structure function relationships in regulating GTP exchange and GTPases |
| GPCRs and Their Modulation |
Coupling functions of GPCRs and their regulation by GRKs |
| G Protein Effectors |
Adenylyl cyclases, phospholipase C |
| Discussion Forum |
All lecturers in this section may participate in this class, or a single lecturer may guide the discussion. |
| Part 3: Signal Transduction Through Ion Channels |
A different lecturer may present each topic, and a single person should be selected as the coordinator for this section. |
| Ligand-Gated Channels |
Structure and function of Nicotinic Ach receptors and glutamate receptors |
| Regulation of Ion Channels by G Proteins |
K+ and Ca2+ channels as G protein effectors |
| Transient Receptor Protein (TRP) Channels |
Diversity of TRP channels and their role in touch, heat, and pain perception |
| Discussion Forum |
All lecturers in this section may participate in this class, or a single lecturer may guide the discussion. |
| Part 4: Signals with Long-Term Consequences |
A different lecturer may present each topic, and a single person should be selected as the coordinator for this section. |
| Proteases and Signaling |
Ubiquitin-proteasome pathways in signaling |
| Apoptosis |
Caspase pathways
|
| Cytokine Receptors |
Janus kinase and signal transducer and activator of transcription (JAK-STAT) signaling |
| Toll-Like Receptors |
Signaling in innate immunity |
| Discussion Forum |
All lecturers in this section may participate in this class, or a single lecturer may guide the discussion. |
| Part 5: Regulation of Transcription and Translation |
A different lecturer may present each topic, and a single person should be selected as the coordinator for this section. |
| Nuclear Transactivators and Repressors |
Signaling input into transcriptional regulation |
| Chromatin Remodeling |
Regulation of higher order organization in transcription |
| Nuclear Receptors |
Signaling by steroid hormone receptors |
| Regulation of Translation |
Regulation of mRNA stability and mRNA-ribosome interactions |
| Discussion Forum |
All lecturers in this section may participate in this class, or a single lecturer may guide the discussion. |
| Part 6: Recent Advances in Signaling Research |
A different lecturer may present each topic, and a single person should be selected as the coordinator for this section. |
| Modeling of Signaling Networks |
Choosing different types of mathematical representation to build predictive models |
| Assembly and Organization of Macromolecular Complexes |
Signaling regulation by anchors and scaffolds |
| Regulation of Complexes by Cytoskeletal Elements |
Dynamics of anchoring |
| Imaging Signaling Reactions in the Live Cell |
Fluorescence imaging of biochemical reactions in the cell |
| Discussion Forum |
All lecturers in this section may participate in this class, or a single lecturer may guide the discussion. |
| Part 7: Systems Biology of Signaling |
A different lecturer may present each topic, and a single person should be selected as the coordinator for this section. |
| Building a Vertebrate Embryo |
Pathways that integrate the formation of three primary germ layers |
| Sensory Systems |
Focus on taste transduction systems |
| Long-Term Potentiation (LTP) |
Pathways regulating learning and memory in hippocampal CA1 neurons |
| Discussion Forum |
All lecturers in this section may participate in this class, or a single lecturer may guide the discussion. |
| Wrap-up Discussion Forum |
All lecturers in this section may participate in this class, or a single lecturer may guide the discussion. |
