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Cell Signaling Systems: A Course for Graduate Students General Syllabus

Ravi Iyengar*, Maria Diverse-Pierluissi, Daniel Weinstein, and Lakshmi Devi

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029 USA.

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*Corresponding author. E-mail: ravi.iyengar{at}mssm.edu

This syllabus is based on the course taught at The Dorothy H. and Lewis Rosenstiel Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine (http://www.mssm.edu/pharmacology/) in Spring 2005. Information about the course coordinator, Ravi Iyengar, can be found on his faculty web page (http://directory.mssm.edu/faculty/facultyInfo.php?id=18800&deptid=30).

Section and lecture title Brief content and organizational comments
Part 1: Principles of Cell Signaling Systems A different lecturer may present each topic, and a single person should be selected as the coordinator for this section.
General Introduction and Introduction to G Protein-Coupled Receptor (GPCR) Signaling Principles underlying cell communication with a focus on heterotrimeric G protein pathways
Growth Factor/Receptor Tyrosine Kinases (RTKs) and Wnt Receptors Initiation of signaling through classical growth factor receptors and Wnt pathways
Ras to Mitogen-Activated Protein Kinase (MAPK) Pathways Classical signaling pathways to MAPKs
Protein Kinases Structure-function relationships and regulation of protein functions through phosphorylation
Protein Phosphatases Structure/function relationships and regulation of protein function by phosphatases
Domains in RTKs: Structural Aspects Protein domains in signaling: SH2, PTB domains
Discussion Forum All lecturers in this section may participate in this class, or a single lecturer may guide the discussion.
Part 2: G Protein Signaling A different lecturer may present each topic, and a single person should be selected as the coordinator for this section.
Structure of GPCRs, G proteins, and GTPases Structure function relationships in regulating GTP exchange and GTPases
GPCRs and Their Modulation Coupling functions of GPCRs and their regulation by GRKs
G Protein Effectors Adenylyl cyclases, phospholipase C
Discussion Forum All lecturers in this section may participate in this class, or a single lecturer may guide the discussion.
Part 3: Signal Transduction Through Ion Channels A different lecturer may present each topic, and a single person should be selected as the coordinator for this section.
Ligand-Gated Channels Structure and function of Nicotinic Ach receptors and glutamate receptors
Regulation of Ion Channels by G Proteins K+ and Ca2+ channels as G protein effectors
Transient Receptor Protein (TRP) Channels Diversity of TRP channels and their role in touch, heat, and pain perception
Discussion Forum All lecturers in this section may participate in this class, or a single lecturer may guide the discussion.
Part 4: Signals with Long-Term Consequences A different lecturer may present each topic, and a single person should be selected as the coordinator for this section.
Proteases and Signaling Ubiquitin-proteasome pathways in signaling
Apoptosis Caspase pathways
Cytokine Receptors Janus kinase and signal transducer and activator of transcription (JAK-STAT) signaling
Toll-Like Receptors Signaling in innate immunity
Discussion Forum All lecturers in this section may participate in this class, or a single lecturer may guide the discussion.
Part 5: Regulation of Transcription and Translation A different lecturer may present each topic, and a single person should be selected as the coordinator for this section.
Nuclear Transactivators and Repressors Signaling input into transcriptional regulation
Chromatin Remodeling Regulation of higher order organization in transcription
Nuclear Receptors Signaling by steroid hormone receptors
Regulation of Translation Regulation of mRNA stability and mRNA-ribosome interactions
Discussion Forum All lecturers in this section may participate in this class, or a single lecturer may guide the discussion.
Part 6: Recent Advances in Signaling Research A different lecturer may present each topic, and a single person should be selected as the coordinator for this section.
Modeling of Signaling Networks Choosing different types of mathematical representation to build predictive models
Assembly and Organization of Macromolecular Complexes Signaling regulation by anchors and scaffolds
Regulation of Complexes by Cytoskeletal Elements Dynamics of anchoring
Imaging Signaling Reactions in the Live Cell Fluorescence imaging of biochemical reactions in the cell
Discussion Forum All lecturers in this section may participate in this class, or a single lecturer may guide the discussion.
Part 7: Systems Biology of Signaling A different lecturer may present each topic, and a single person should be selected as the coordinator for this section.
Building a Vertebrate Embryo Pathways that integrate the formation of three primary germ layers
Sensory Systems Focus on taste transduction systems
Long-Term Potentiation (LTP) Pathways regulating learning and memory in hippocampal CA1 neurons
Discussion Forum All lecturers in this section may participate in this class, or a single lecturer may guide the discussion.
Wrap-up Discussion Forum All lecturers in this section may participate in this class, or a single lecturer may guide the discussion.

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Citation: R. Iyengar, M. Diverse-Pierluissi, D. Weinstein, L. A. Devi, Cell signaling systems: A course for graduate students. Sci. STKE 2005, tr3 (2005).

© 2005 American Association for the Advancement of Science


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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882