Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Cell Signaling Systems: A Course for Graduate Students
Syllabus for Mount Sinai School of Medicine Spring 2005

Ravi Iyengar*, Maria Diverse-Pierluissi, Daniel Weinstein, and Lakshmi Devi

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Corresponding author. E-mail: ravi.iyengar{at}

This syllabus is based on the course taught at The Dorothy H. and Lewis Rosenstiel Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine ( in Spring 2005. Except where noted, all faculty listed are from Mount Sinai School of Medicine and contact information is available from and the URLs to their faculty pages are provided below.

1 Christian Schindler is faculty at Columbia University.

2 Neal Lue is faculty at Weill Medical College of Cornell University.

3 Mark Philips is faculty at New York University,

Section Lecturer (*section coordinator) Faculty Web page
Part 1: Principles of Cell Signaling Systems
General Introduction and Introduction to G Protein-Coupled Receptor (GPCR) Signaling Ravi Iyengar*
Growth Factor and Receptor Tyrosine Kinases (RTKs) and the Wnt Pathway Stuart Aaronson
Ras to Mitogen-Activated Protein Kinase (MAPK) Pathways Andrew Chan
Kinases Avrom Caplan
Phosphatases Stephen Salton
Domains in RTKs: Structural Aspects Ming-Ming Zhou
Discussion Forum Andrew Chan
Part 2: G Protein Signaling
Structure of GPCRs and G Proteins Ravi Iyengar
GPCRs Stuart Sealfon
G Protein Effectors Maria Diverse
Discussion Forum Lakshmi Devi*
Part 3: Signal Transduction Through Ion Channels
Ligand-Gated Channels Robert Blitzer
Regulation of Ion Channels by G Proteins Maria Diverse*
Transient Receptor Protein (TRP) Channels Tibor Rohacs
Discussion Forum Maria Diverse*
Part 4: Signals with Long-Term Consequences
Proteases and Signaling Sherwin Wilk*
Apoptosis Sherwin Wilk*
Cytokine Receptors-Janus Kinase and Signal Transducer and Activator of Transcription (JAK-STAT) Signaling Christian Schindler1
Toll-Like Receptors Maria Abreu
Discussion Forum Sherwin Wilk*
Part 5: Regulation of Transcription and Translation
Nuclear Transactivators and Repressors Zhen-Qiang Pan
Chromatin Remodeling Neal Lue2
Nuclear Receptors Reshma Taneja
Regulation of Translation Emmanuel Landau
Discussion Forum Daniel Weinstein*
Part 6: Recent Advances in Signaling Research
Modeling of Signaling Networks Ravi Iyengar
Assembly and Organization of Macromolecular Complexes Ravi Iyengar
Regulation of Complexes by Cytoskeletal Elements Dan Felsenfeld
Imaging Signaling Reactions in the Live Cell Mark Philips3
Discussion Forum Lakshmi Devi* and Maria Diverse*
Part 7: Systems Biology of Signaling
Mesodermal Differentiation Daniel Weinstein*
Sensory Systems Robert Margolskee
Long-Term Potentiation (LTP) Robert Blitzer
Discussion Forum Marianna Max
Wrap-up Discussion Forum Ravi Iyengar*


Citation: R. Iyengar, M. Diverse-Pierluissi, D. Weinstein, L. A. Devi, Cell signaling systems: A course for graduate students. Sci. STKE 2005, tr3 (2005).

© 2005 American Association for the Advancement of Science

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882