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Sci. Signal., 23 March 2010
[DOI: 10.1126/scisignal.2000818]

Supplementary Materials for:

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease–Linked Presenilin Mutants in Human Cells and Mouse Neurons

King-Ho Cheung, Lijuan Mei, Don-On Daniel Mak, Ikuo Hayashi, Takeshi Iwatsubo, David E. Kang, J. Kevin Foskett*

*To whom correspondence should be addressed. E-mail: foskett{at}mail.med.upenn.edu

This PDF file includes:

  • Fig. S1. Recombinant presenilins in baculovirus-infected Sf9 cells.
  • Fig. S2. Modal gating analyses of IP3R channels under the influence of FAD-linked mutant PS.
  • Fig. S3. Effect of xestospongin B on IgM-activated Ca2+ oscillations in human B lymphoblasts.
  • Fig. S4. FAD PS enhances IP3R channel gating by gain-of-function effect.
  • Reference

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Technical Details

Format: Adobe Acrobat PDF

Size: 1.5 MB


Citation: K.-H. Cheung, L. Mei, D.-O. D. Mak, I. Hayashi, T. Iwatsubo, D.E. Kang, J. K. Foskett, Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease–Linked Presenilin Mutants in Human Cells and Mouse Neurons. Sci. Signal. 3, ra22 (2010).

© 2010 American Association for the Advancement of Science


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