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Sci. Signal., 25 May 2010
[DOI: 10.1126/scisignal.2000751]

Supplementary Materials for:

TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy

Chong-Shan Shi* and John H. Kehrl*

*To whom correspondence should be addressed. E-mail: cshi{at}niaid.nih.gov (C.-S.S.); jkehrl{at}niaid.nih.gov (J.H.K.)

This PDF file includes:

  • Fig. S1. LPS-induced K63-linked ubiquitination of Beclin-1 and autophagy in primary human monocytes.
  • Fig. S2. IL-1 stimulates the ubiquitination of Beclin-1 and triggers autophagy.
  • Fig. S3. LPS and TRAF6 increase autophagic flux in RAW 264.7 cells.
  • Fig. S4. IFN-γ and starvation induce the ubiquitination of Beclin-1.

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Citation: C.-S. Shi, J. H. Kehrl, TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy. Sci. Signal. 3, ra42 (2010).

© 2010 American Association for the Advancement of Science


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