Akt–RSK–S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases

Albrecht Moritz, Yu Li, Ailan Guo, Judit Villén, Yi Wang, Joan MacNeill, Jon Kornhauser, Kam Sprott, Jing Zhou, Anthony Possemato, Jian Min Ren, Peter Hornbeck, Lewis C. Cantley, Steven P. Gygi, John Rush, Michael J. Comb*

*To whom correspondence should be addressed. E-mail: mcomb{at}cellsignal.com

This PDF file includes:

• Materials and Methods
• Fig. S1. Phosphorylation of SGTA at Ser³⁰⁵
• Fig. S2. Akt–RSK–S6 kinase networks downstream of RTKs
• Reference

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Other Supplementary Material for this manuscript includes the following:

• Table S1. Summary of all peptide assignments from all mass spectrometric experiments in this study (Microsoft Excel format).
• Table S2. Proteins with phosphorylation of RxRxxS*/T* or RxxS*/T* sites changed by inhibitors (Microsoft Excel format).
• Table S3. Proteins with phosphorylation of both RxRxxS*/T* (or RxxS*/T* sites) and pY sites changed by RTK inhibitors (overlap) (Microsoft Excel format).
• Table S4. Thirty-three proteins tested in siRNA inhibition experiments (Microsoft Excel format).

© 2010 American Association for the Advancement of Science