A Conceptual Molecular Network for Chemotactic Behaviors
Characterized by Feedback of Molecules Cycling Between the
Membrane and the Cytosol

Mikiya Otsuji,* Yuya Terashima, Shuji Ishihara, Shinya Kuroda, Kouji Matsushima*

*To whom correspondence should be addressed. E-mail: mohtsuji-tky{at}umin.ac.jp (M.O.); koujim{at}m.u-tokyo.ac.jp (K.M.)

This PDF file includes:

• Section 1. Analytical examination of the instabilities of the MCRD system.
• Section 2. Simulations.
• Section 3. Observation of chemotaxing cells.
• Section 4. MCRD system with restriction mechanism.
• References
• Fig. S1. Analysis of chemotaxing cells.
• Fig. S2. A system that generates both SSA and S&C patterns.
• Fig. S3. Instability-2 and Instability-3.
• Fig. S4. An MCRD system with an infinitely large D_c.
• Fig. S5. Stable single axis with oscillation (SSAo).
• Fig. S6. The 3S-MCRD system with a restriction mechanism.
• Fig. S7. Competition between two peaks by Instability-1 in the S&C pattern.
• Fig. S8. Dependency of the growth rate of instabilities on the number of peaks.
• Fig. S9. Chemotaxing cells with multiple unstable pseudopods.
• Fig. S10. Chemotaxing cells exhibiting a seesaw pattern of migration.
• Fig. S11. Simulations for understanding right-left bias.
• Table S1. Parameter values used in computation for verification of analysis.
• Table S2. Parameter values used in the simulations.
• Descriptions of Movies S1 to S3.
  

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Other Supplementary Material for this manuscript includes the following:

• Movie S1 (.mov format). Chemotaxing cells.
• Movie S2 (.mov format). S&C behavior generated by the 2S-MCRD system.
• Movie S3 (.mov format). S&C behavior generated by the 3S-MCRD system.
  

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File Sizes: 1,424 KB (Movie S1); 1,825 KB (Movie S2); 1,974 KB (Movie S3)

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