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Sci. Signal., 15 February 2011
[DOI: 10.1126/scisignal.2001426]

Supplementary Materials for:

MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop

Rehan Ahmad, Hasan Rajabi, Michio Kosugi, Maya Datt Joshi, Maroof Alam, Baldev Vasir, Takeshi Kawano, Surender Kharbanda, Donald Kufe*

*To whom correspondence should be addressed. E-mail: donald_kufe{at}dfci.harvard.edu

This PDF file includes:

  • Fig. S1. Immunoblot analysis of MUC1-C in lysates from WI-38 fibroblasts and MCF-7 breast cancer cells.
  • Fig. S2. Association of STAT3 and MUC1-C with the STAT binding region of the MUC1 promoter in MCF-7 cells.
  • Fig. S3. IL-6 induces STAT3 association with the MUC1 promoter in MCF-10A cells.
  • Fig. S4. IL-6 increases MUC1 mRNA in MCF-10A cells.
  • Fig. S5. Effects of GO-201 on IL-6–induced association of STAT3 and MUC1-C with the MUC1, STAT3, and cyclin D1 promoters in MCF-10A cells.
  • Fig. S6. Effects of GO-201 on EGFR phosphorylation in ZR-75-1 cells.

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Citation: R. Ahmad, H. Rajabi, M. Kosugi, M. D. Joshi, M. Alam, B. Vasir, T. Kawano, S. Kharbanda, D. Kufe, MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop. Sci. Signal. 4, ra9 (2011).

© 2011 American Association for the Advancement of Science

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