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Sci. Signal., 12 July 2011
[DOI: 10.1126/scisignal.2001925]

Supplementary Materials for:

The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia

Qin Liu, Hao-Jui Weng, Kush N. Patel, Zongxiang Tang, Haihua Bai, Martin Steinhoff, Xinzhong Dong*

*To whom correspondence should be addressed. E-mail: xdong2{at}jhmi.edu

This PDF file includes:

  • Fig. S1. Dose-response curves to SLIGRL for dissociated wild-type DRG neurons.
  • Fig. S2. SLIGRL fails to activate other mouse Mrgprs.
  • Fig. S3. The entire sequence of SLIGRL is required for the activation of MrgprC11.
  • Fig. S4. SLIGKV specifically activates human MrgprX2.
  • Fig. S5. RT-PCR analysis of DRG from WT (+/+), PAR2–/–, and Mrgpr-clusterΔ–/– mice (Mrgpr–/–) mice for the abundance of mRNAs encoding PAR2, MrgprC11, and actin.
  • References

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Format: Adobe Acrobat PDF

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Citation: Q. Liu, H.-J. Weng, K. N. Patel, Z. Tang, H. Bai, M. Steinhoff, X. Dong, The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia. Sci. Signal. 4, ra45 (2011).

© 2011 American Association for the Advancement of Science


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