The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia

Qin Liu, Hao-Jui Weng, Kush N. Patel, Zongxiang Tang, Haihua Bai, Martin Steinhoff, Xinzhong Dong*

*To whom correspondence should be addressed. E-mail: xdong2{at}jhmi.edu

This PDF file includes:

• Fig. S1. Dose-response curves to SLIGRL for dissociated wild-type DRG neurons.
• Fig. S2. SLIGRL fails to activate other mouse Mrgprs.
• Fig. S3. The entire sequence of SLIGRL is required for the activation of MrgprC11.
• Fig. S4. SLIGKV specifically activates human MrgprX2.
• Fig. S5. RT-PCR analysis of DRG from WT (+/+), PAR2^–/–, and Mrgpr-clusterΔ^–/– mice (Mrgpr^–/–) mice for the abundance of mRNAs encoding PAR2, MrgprC11, and actin.
• References
  

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 528 KB

© 2011 American Association for the Advancement of Science