Load-Induced Modulation of Signal Transduction Networks

Peng Jiang, Alejandra C. Ventura, Eduardo D. Sontag, Sofia D. Merajver, Alexander J. Ninfa,* Domitilla Del Vecchio*

*To whom correspondence should be addressed. E-mail: aninfa{at}umich.edu (A.J.N.); ddv{at}mit.edu (D.D.V.)

This PDF file includes:

• Text
• Fig. S1. Steady-state effects of loading.
• Fig. S2. Effect of loading on the frequency response.
• Fig. S3. Effects of enzyme amounts.
• Fig. S4. Effect of the load on the amplitude of response to a train of pulses.
• Fig. S5. Response of the UTase/UR–PII cycle to stimulation with nonsaturating concentrations of glutamine.
• Fig. S6. Using glutaminase and injections of glutamine to impose time-varying input stimulation.
• Fig. S7. Amplitude of the initial response to glutamine addition depends on whether or not the system has achieved a steady state before glutamine addition.
• References

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© 2011 American Association for the Advancement of Science