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Sci. Signal., 25 October 2011
[DOI: 10.1126/scisignal.2002278]

Supplementary Materials for:

Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size

Mei Xin, Yuri Kim, Lillian B. Sutherland, Xiaoxia Qi, John McAnally, Robert J. Schwartz, James A. Richardson, Rhonda Bassel-Duby, Eric N. Olson*

*To whom correspondence should be addressed. E-mail: eric.olson{at}utsouthwestern.edu

This PDF file includes:

  • Fig. S1. Generation of mice with a conditional Yap mutation.
  • Fig. S2. Yap promotes proliferation of embryonic cardiomyocytes in vivo.
  • Fig. S3. Yap induces cell cycle reentry and division of cardiomyocytes in vitro.
  • Fig. S4. Yap activates the IGF and β-catenin signaling pathways and activates genes encoding cell cycle regulators.
  • Reference

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Technical Details

Format: Adobe Acrobat PDF

Size: 1.2 MB


Citation: M. Xin, Y. Kim, L. B. Sutherland, X. Qi, J. McAnally, R. J. Schwartz, J. A. Richardson, R. Bassel-Duby, E. N. Olson, Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size. Sci. Signal. 4, ra70 (2011).

© 2011 American Association for the Advancement of Science


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