The Long-Term Survival Potential of Mature T Lymphocytes Is Programmed During Development in the Thymus

Charles Sinclair, Manoj Saini, Ina Schim van der Loeff, Shimon Sakaguchi, Benedict Seddon*

*To whom correspondence should be addressed. E-mail: bseddon{at}nimr.mrc.ac.uk

This PDF file includes:

• Fig. S1. IL-7Rα abundance on peripheral T cells from F5 and OT-I mice is not tuned by spMHC contact in replete b2m^–/– hosts.
• Fig. S2. Prior contact of F5 T cells with spMHC does not determine their proliferative response to IL-7 in vitro.
• Fig. S3. IL-7Rα abundance and function in OT-I T cells in the absence of TCR ligands are normal.
• Fig. S4. CD8 abundance on CD8⁺ cells from TCR transgenic and Zap70 mutant mice is unchanged.
• Fig. S5. IL-7Rα abundance inversely correlates with clonal competition in mixed bone marrow chimeric mice.
• Fig. S6. IL-7Rα^hi and IL-7Rα^lo CD4⁺ SP thymocytes have equivalent maturation phenotypes.
  

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© 2011 American Association for the Advancement of Science