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Sci. Signal., 6 December 2011
[DOI: 10.1126/scisignal.2002060]

Supplementary Materials for:

Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor
Signaling Through Rac

Katrin Deinhardt, Taeho Kim, Daniel S. Spellman, Richard E. Mains, Betty A. Eipper,
Thomas A. Neubert, Moses V. Chao, Barbara L. Hempstead*

*To whom correspondence should be addressed. E-mail: blhempst{at}

This PDF file includes:

  • Methods
  • Fig. S1. Two additional examples showing proNGF-induced growth cone collapse.
  • Fig. S2. p75NTR and SorCS2 are the receptors mediating growth cone retraction.
  • Fig. S3. Identification of Trio.
  • Fig. S4. Generation of the kinase-dead Trio mutant.
  • Fig. S5. Decrease of Rac but not RhoA activity induces growth cone collapse.
  • Fig. S6. Fascin and p75NTR form a complex in embryonic brain lysates.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 612 KB

Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). ProNGF leads to growth cone collapse.

Technical Details

Format: QuickTime movie

Size: 526 KB

Citation: K. Deinhardt, T. Kim, D. S. Spellman, R. E. Mains, B. A. Eipper, T. A. Neubert, M. V. Chao, B. L. Hempstead, Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac. Sci. Signal. 4, ra82 (2011).

© 2011 American Association for the Advancement of Science

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