Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 3 April 2012
[DOI: 10.1126/scisignal.2002549]

Supplementary Materials for:

A Large Bioactive BMP Ligand with Distinct Signaling Properties Is Produced by Alternative Proconvertase Processing

Takuya Akiyama, Guillermo Marqués, Kristi A. Wharton*

*To whom correspondence should be addressed. E-mail: kristi_wharton{at}brown.edu

This PDF file includes:

  • Fig. S1. Signaling activity of the HA-tagged Gbb constructs.
  • Fig. S2. Gbb38 and Gbb15 bind to the Sax type I receptor.
  • Fig. S3. Signaling activity of the hBMP4 and hBMP4 cleavage mutants.
  • Fig. S4. Failure to cleave Gbb at the NS results in wing defects.
  • Fig. S5. The gbb double cleavage mutant exhibits dominant-negative behavior when expressed in dpp-expressing cells of the wing imaginal disc.
  • Fig. S6. Wild-type gbb (Gbb38 and Gbb15) and gbbmS1 (Gbb38) exhibit nonautonomous signaling.
  • Table S1. Macrochaetae and leg defects associated with misexpression of gbb and gbb cleavage mutants in dpp-expressing cells.
  • Table S2. Primers used in this study.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 589 KB


Citation: T. Akiyama, G. Marqués, K. A. Wharton, A Large Bioactive BMP Ligand with Distinct Signaling Properties Is Produced by Alternative Proconvertase Processing. Sci. Signal. 5, ra28 (2012).

© 2012 American Association for the Advancement of Science


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882