Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 1 May 2012
[DOI: 10.1126/scisignal.2002733]

Supplementary Materials for:

Genomic Survey of Premetazoans Shows Deep Conservation of Cytoplasmic Tyrosine Kinases and Multiple Radiations of Receptor Tyrosine Kinases

Hiroshi Suga,* Michael Dacre, Alex de Mendoza, Kamran Shalchian-Tabrizi, Gerard Manning,* Iñaki Ruiz-Trillo*

*To whom correspondence should be addressed. E-mail: hiroshi.suga{at}ibe.upf-csic.es (H.S.); manning{at}manninglab.org (G.M.); inaki.ruiz{at}icrea.es (I.R.-T.)

This PDF file includes:

  • Fig. S1. Protein domain organizations of all of the TKs of C. owczarzaki and M. vibrans.
  • Fig. S2. Phylogenetic position of TKs in the ePK superfamily.
  • Fig. S3. ML analysis of the phylogenetic positions of TKs and a test of the hypothesis of the multiple origins of TKs.
  • Fig. S4. Bayesian and ML analyses of ePKs without TKs.
  • Fig. S5. Statistical tests of the group A position.
  • Fig. S6. Statistical test of the group-level clustering of TKs.
  • Fig. S7. Phylogenetic tree and domain architectures of holozoan TKs.
  • Fig. S8. ML tree and protein domain organizations of cluster I TKs of C. owczarzaki.
  • Fig. S9. Diversification of A. queenslandica RTKs in cluster II.
  • Fig. S10. An ML tree excluding biased sequences and rapidly evolving sequences.
  • Fig. S11. TK families of six holozoans.
  • Fig. S12. Phylogenetic tree of CTKs.
  • Fig. S13. Protein domain organizations of TKs from three choanoflagellates and their comparison with the M. brevicollis TK repertoire.
  • Fig. S14. Comparison of three C. owczarzaki receptor proteins with very similar extracellular regions.
  • Fig. S15. Alignment of ePKs.
  • Fig. S16. Alignment of holozoan TKs.
  • References

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 8.55 MB

Other Supplementary Material for this manuscript includes the following:

  • Sequence data (PDF format)

[Download Sequence Data]

Technical Details

Format: Adobe Acrobat PDF

Size: 543 KB


Citation: H. Suga, M. Dacre, A. de Mendoza, K. Shalchian-Tabrizi, G. Manning, I. Ruiz-Trillo, Genomic Survey of Premetazoans Shows Deep Conservation of Cytoplasmic Tyrosine Kinases and Multiple Radiations of Receptor Tyrosine Kinases. Sci. Signal. 5, ra35 (2012).

© 2012 American Association for the Advancement of Science


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882