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Sci. Signal., 17 July 2012
[DOI: 10.1126/scisignal.2002581]

Supplementary Materials for:

Epidermal Growth Factor Receptor Is Essential for Toll-Like Receptor 3 Signaling

Michifumi Yamashita, Saurabh Chattopadhyay, Volker Fensterl, Paramananda Saikia, Jaime L. Wetzel, Ganes C. Sen*

*To whom correspondence should be addressed. E-mail: seng{at}

This PDF file includes:

  • Fig. S1. EGFR is required for TLR3 signaling, but not RIG-I signaling.
  • Fig. S2. LRRK1 is not required for TLR3 signaling or the constitutive early endosomal localization of EGFR.
  • Fig. S3. Src interaction with TLR3 is independent of TRIF, but dependent on EGFR.
  • Fig. S4. The protein tyrosine kinase activities of Src and EGFR are required for phosphorylation of Tyr759 and Tyr858 in TLR3.

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Technical Details

Format: Adobe Acrobat PDF

Size: 718 KB

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Microarray analysis of TLR3 signaling–mediated gene induction in wild-type and EGFR-expressing MDA-MB-453 cells.

Technical Details

Format: Microsoft Excel

Size: 90 KB

Citation: M. Yamashita, S. Chattopadhyay, V. Fensterl, P. Saikia, J. L. Wetzel, G. C. Sen, Epidermal Growth Factor Receptor Is Essential for Toll-Like Receptor 3 Signaling. Sci. Signal. 5, ra50 (2012).

© 2012 American Association for the Advancement of Science

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