Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 7 August 2012
[DOI: 10.1126/scisignal.2002456]

Supplementary Materials for:

Nucleolar Localization of a Netrin-1 Isoform Enhances Tumor Cell Proliferation

Céline Delloye-Bourgeois, David Goldschneider, Andrea Paradisi, Gabriel Therizols, Stéphane Belin, Sabine Hacot, Manuel Rosa-Calatrava, Jean-Yves Scoazec, Jean-Jacques Diaz, Agnès Bernet, Patrick Mehlen*

*To whom correspondence should be addressed. E-mail: patrick.mehlen{at}lyon.unicancer.fr

This PDF file includes:

  • Fig. S1. Depletion of ΔN-netrin-1 affects B23 localization within the nucleolus in IMR32 cells.
  • Fig. S2. Depletion of ΔN-netrin-1 affects B23 localization in the nucleolus in H358 cells.
  • Fig. S3. Netrin-1 colocalizes with B23 and nucleolin in the nucleolus.
  • Fig. S4. Characterization of the netrin-1 alternative promoter and ΔN-netrin-1.
  • Fig. S5. ΔN-netrin-1 specifically associates with ribosomal DNA.
  • Fig. S6. ΔN-netrin-1 promotes ribosome biogenesis.
  • Fig. S7. Nucleolar ΔN-netrin-1 promotes cell proliferation.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 608 KB


Citation: C. Delloye-Bourgeois, D. Goldschneider, A. Paradisi, G. Therizols, S. Belin, S. Hacot, M. Rosa-Calatrava, J.-Y. Scoazec, J.-J. Diaz, A. Bernet, P. Mehlen, Nucleolar Localization of a Netrin-1 Isoform Enhances Tumor Cell Proliferation. Sci. Signal. 5, ra57 (2012).

© 2012 American Association for the Advancement of Science


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882