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Sci. Signal., 25 September 2012
[DOI: 10.1126/scisignal.2003084]

Supplementary Materials for:

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

Ulrich Putz, Jason Howitt, Anh Doan, Choo-Peng Goh, Ley-Hian Low, John Silke, Seong-Seng Tan*

*To whom correspondence should be addressed. E-mail: sst{at}unimelb.edu.au

This PDF file includes:

  • Fig. S1. Cell cytotoxicity assays and internalization of dye-labeled exosomes in recipient MEFs.
  • Fig. S2. Uptake of exosomal Ndfip1 by Ndfip1+/+ and Ndfip1–/– MEFs.
  • Fig. S3. PTEN from exosomes reduces pAkt abundance in PTEN-deficient recipient cells.

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Technical Details

Format: Adobe Acrobat PDF

Size: 1 MB


Citation: U. Putz, J. Howitt, A. Doan, C.-P. Goh, L.-H. Low, J. Silke, S.-S. Tan, The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells. Sci. Signal. 5, ra70 (2012).

© 2012 American Association for the Advancement of Science


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