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Sci. Signal., 27 November 2012
[DOI: 10.1126/scisignal.2003365]

Supplementary Materials for:

Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

Rebecca J. Brownlie, Lisa A. Miosge, Demetrios Vassilakos, Lena M. Svensson, Andrew Cope, Rose Zamoyska*

*To whom correspondence should be addressed. E-mail: rose.zamoyska{at}ed.ac.uk

This PDF file includes:

  • Fig. S1. Generation of a conditional allele of Ptpn22.
  • Fig. S2. Normal thymocyte differentiation in Ptpn22–/– mice.
  • Fig. S3. CD4+ and CD8+ effector/memory cells are increased in number in Ptpn22–/– mice.
  • Fig. S4. Deficiency in PTPN22 results in increased total serum Ig concentrations.
  • Fig. S5. Ptpn22–/+ Tregs have an intermediate phenotype between those of wild-type and Ptpn22–/– Tregs.
  • Fig. S6. TCR signaling is enhanced in Ptpn22–/– effector T cells.
  • Table S1. Ptpn22–/– Tregs have an activated phenotype.

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Technical Details

Format: Adobe Acrobat PDF

Size: 1.43 MB


Citation: R. J. Brownlie, L. A. Miosge, D. Vassilakos, L. M. Svensson, A. Cope, R. Zamoyska, Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function. Sci. Signal. 5, ra87 (2012).

© 2012 American Association for the Advancement of Science


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