The Homeobox Transcription Factor Cut Coordinates Patterning and Growth During Drosophila Airway Remodeling

Chrysoula Pitsouli* and Norbert Perrimon*

*To whom correspondence should be addressed. E-mail: pitsouli{at}ucy.ac.cy (C.P.); perrimon{at}receptor.med.harvard.edu (N.P.)

This PDF file includes:

• Fig. S1. The Cut gradient in flies of different genotypes and stages.
• Fig. S2. Signaling pathway genes are differentially expressed in zone 1 and zone 3 SB cells.
• Fig. S3. The Notch and Wg pathways are activated during early SB development.
• Fig. S4. A temperature-sensitive UAS-cut^RNAi line recapitulates the loss of cut.
• Fig. S5. p35 prevents the apoptosis induced by expression of UAS-cut^RNAi at 18°C and 25°C.
• Fig. S6. Scheme for ectopic expression of cut in zone 1 cells.
• Fig. S7. Transcriptional effects of cut knockdown on signaling pathway genes in zone 3.
• Tables S1 to S4 legends

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Other Supplementary Material for this manuscript includes the following:

• Table S1 (Microsoft Excel format). Enrichment of GO categories in zone 1 compared to zone 3.
• Table S2 (Microsoft Excel format). Signaling pathway gene list in Affymetrix Drosophila Genome 2.0 arrays.
• Table S3 (Microsoft Excel format). Enrichment of GO categories in wild-type zone 1 compared to cutOE zone 1.
• Table S4 (Microsoft Excel format). qPCR primer sequences.

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© 2013 American Association for the Advancement of Science