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Sci. Signal., 12 March 2013
[DOI: 10.1126/scisignal.2003706]

Supplementary Materials for:

Signaling by p38 MAPK Stimulates Nuclear Localization of the Microprocessor Component p68 for Processing of Selected Primary MicroRNAs

Sungguan Hong, Hyangsoon Noh, Haoming Chen, Ravi Padia, Zhixing K. Pan, Shi-Bing Su, Qing Jing, Han-Fei Ding, Shuang Huang*

*Corresponding author. E-mail: shuang{at}gru.edu

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Western blotting analysis of MK2 abundance.
  • Fig. S2. Microarray analysis comparing the relative expression of 345 miRNAs in wild-type and MK2−/− MEFs.
  • Fig. S3. Mass spectrometry analysis of the MK2-dependent phosphorylation of p68.
  • Fig. S4. The p72 protein physically interacts with and is a substrate of MK2.
  • Fig. S5. Assessment of the knockdown of p68 in wild-type MEFs.
  • Table S1. The binding partners of MK2 as determined by yeast two-hybrid screening.
  • Reference (50)

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Technical Details

Format: Adobe Acrobat PDF

Size: 3.38 MB


Citation: S. Hong, H. Noh, H. Chen, R. Padia, Z. K. Pan, S.-B. Su, Q. Jing, H.-F. Ding, S. Huang, Signaling by p38 MAPK Stimulates Nuclear Localization of the Microprocessor Component p68 for Processing of Selected Primary MicroRNAs. Sci. Signal. 6, ra16 (2013).

© 2013 American Association for the Advancement of Science


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