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Sci. Signal., 9 July 2013
[DOI: 10.1126/scisignal.2003727]

Supplementary Materials for:

JNK3 Couples the Neuronal Stress Response to Inhibition of Secretory Trafficking

Guang Yang,* Xun Zhou, Jingyan Zhu, Rui Liu, Si Zhang, Ainsley Coquinco, Yongting Chen, Yanhua Wen, Luba Kojic, William Jia, Max S. Cynader*

*Corresponding author. E-mail: cynader{at}brain.ubc.ca (M.S.C.); photonyg{at}interchange.ubc.ca (G.Y.)

This PDF file includes:

  • Fig. S1. Subcellular localization of JNK3 induced by PATs.
  • Fig. S2. Kinase activity–independent localization of JNK3 to the Golgi complex.
  • Fig. S3. Enhanced phosphorylation of palmitoylated JNK3.
  • Fig. S4. Inhibition of VSVG trafficking by palmitoylated JNK3.
  • Fig. S5. Inhibition of vesicle secretion from the Golgi by palmitoylated JNK3.
  • Fig. S6. Reduction of surface GluR1 induced by NMDA excitotoxicity.
  • Fig. S7. Disruption of secretory transport system and depletion of PI4P induced by palmitoylated JNK3.
  • Fig. S8. Reduction of neuronal surface GluR1 induced by Sac1.
  • Fig. S9. Interaction between Sac1 and palmitoylated JNK isoforms.
  • Fig. S10. Identification of two JNK3-binding motifs on Sac1.
  • Fig. S11. Identification of potential Sac1-binding motifs on JNK3.
  • Fig. S12. Enlargement of the Golgi-resident pool of PI4P in neurons by Sac1 knockdown.
  • Fig. S13. Disruption of the Sac1-JNK3 interaction by synthetic blocking peptides.

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Citation: G. Yang, X. Zhou, J. Zhu, R. Liu, S. Zhang, A. Coquinco, Y. Chen, Y. Wen, L. Kojic, W. Jia, M. S. Cynader, JNK3 Couples the Neuronal Stress Response to Inhibition of Secretory Trafficking. Sci. Signal. 6, ra57 (2013).

© 2013 American Association for the Advancement of Science


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