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Sci. Signal., 10 December 2013
[DOI: 10.1126/scisignal.2004633]

Supplementary Materials for:

Interferon-γ Resets Muscle Cell Fate by Stimulating the Sequential Recruitment of JARID2 and PRC2 to Promoters to Repress Myogenesis

Priya Londhe and Judith K. Davie*

*Corresponding author. E-mail: jdavie{at}siumed.edu

This PDF file includes:

  • Fig. S1. CIITA in transfected C2C12 cells is similar in abundance to that in IFN-γ–stimulated untransfected cells.
  • Fig. S2. Muscle-specific genes are repressed in the presence of exogenous CIITA throughout cellular differentiation.
  • Fig. S3. CIITA interacts with pTEFB in muscle cells.
  • Fig. S4. H3K27 is methylated at Hoxb7 in control and CIITA-expressing C2C12 cells on days 2 and 6 of differentiation.
  • Fig. S5. Trimethylation of H3K4 is inhibited in CIITA-expressing C2C12 cells.
  • Fig. S6. H3K9 is not methylated on CIITA-repressed genes.
  • Fig. S7. Phosphorylation of the CTD is inhibited in IFN-γ–stimulated cells.
  • Fig. S8. Genes encoding components of the PRC2 complex are increased in expression in Mdx mice.
  • Fig. S9. Detection of macrophages in the liver, but not muscle, of mice injected with IFN-γ–producing CHO cells.

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Citation: P. Londhe, J. K. Davie, Interferon-γ Resets Muscle Cell Fate by Stimulating the Sequential Recruitment of JARID2 and PRC2 to Promoters to Repress Myogenesis. Sci. Signal. 6, ra107 (2013).

© 2013 American Association for the Advancement of Science


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