Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Signal., 28 January 2014
[DOI: 10.1126/scisignal.2004374]

Supplementary Materials for:

ROMO1 Is an Essential Redox-Dependent Regulator of Mitochondrial Dynamics

Matthew Norton, Andy Cheuk-Him Ng, Stephen Baird, Ariane Dumoulin, Timothy Shutt, Nancy Mah, Miguel A. Andrade-Navarro, Heidi M. McBride, Robert A. Screaton*

*Corresponding author. E-mail: rob{at}

This PDF file includes:

  • Fig. S1. The high-throughput mitochondrial morphology screen identifies ROMO1 as a regulator of mitochondrial fusion.
  • Fig. S2. Full-length multiple-sequence alignment of ROMO1 with orthologs.
  • Fig. S3. Reversible oxidation of ROMO1 and rescue of mitochondrial morphology with siRNA-resistant ROMO1 constructs.
  • Fig. S4. ROMO1 associates with, but does not affect, integrity of MINOS.
  • Fig. S5. Normal cellular ATP content and mitochondrial membrane potential in ROMO1 knockdown cells.
  • Fig. S6. Effect of ROMO1 status on OPA1 isoform balance.
  • References (66, 67)

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 8.13 MB


Citation: M. Norton, A. C.-H. Ng, S. Baird, A. Dumoulin, T. Shutt, N. Mah, M. A. Andrade-Navarro, H. M. McBride, R. A. Screaton, ROMO1 Is an Essential Redox-Dependent Regulator of Mitochondrial Dynamics. Sci. Signal. 7, ra10 (2014).

© 2014 American Association for the Advancement of Science

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882