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TGF-β Signaling in Development (Supplemental Table)

Krit Kitisin,1 Tapas Saha,1 Tiffany Blake,1 Nady Golestaneh,1 Merlyn Deng,1 Christine Kim,1 Yi Tang,1 Kirti Shetty,1 Bibhuti Mishra,1 Lopa Mishra1,2*

1Laboratory of Cancer Genetics and Digestive Diseases, Departments of Surgery, Medicine, and LCCC, Georgetown University, Washington, DC 20007, USA. 2DVAMC, Washington, DC 20007, USA.

Supplemental Table. TGF-β signaling in development based on mouse knockout and mutant analysis.

Developmental stage or process Ligands Receptors Intracellular signaling molecules Citations
Primitive streak formation Nodal ALK2,
ActRII,
ActRIIB		 Smad2,
Smad4		 1
Mesoderm formation BMP2,
BMP4,
Nodal		 ALK2,
ALK3,
ALK4		 Smad2,
Smad4		 1, 2
Endoderm formation Cripto,
Nodal,
BMP4		 ALK2,
ActRI		 Smad4 3, 2, 4
Cardiac development BMP2,
Cripto,
Endoglin		 ActRIIB,
ALK2		 Smad4,
Smad5,
Smad6		 5, 6
Kidney development BMP7,
BMP2,
BMP4		 ALK4,
BMPRII,
BMPRIA,
BMPRIB		 Smad1,
Smad4,
Smad5,
Smad8		 7
Bone development TGF-β2,
TGF-β3,
BMP4		 ALK6,
ActRIIA		 Smad1,
Smad5,
Smad8		 1
Liver and gastrointestinal tract development BMP1,
BMP4,
BMP7		 BMPR1A,
ActRII,
ActRIIB		 Smad2,
Smad3,
ELF,
Smad4		 7, 8
Vasculogenesis and hematopoesis TGF-β1 TβRI,
TβRII 		Smad5 9, 10, 11

E-mail, lopamishra{at}yahoo.com

References

  1. M. J. Goumans, C. Mummery, Functional analysis of the TGFβ receptor/Smad pathway through gene ablation in mice. Int. J. Dev. Biol. 44, 253–265 (2000).
  2. C. Sirard, J. L. de la Pompa, A. Elia, A. Itie, C. Mirtsos, A. Cheung, S. Hahn, A. Wakeham, L. Schwartz, S. E. Kern, J. Rossant, T. W. Mak, The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12, 107–119 (1998).
  3. R. Derynck, Y. E. Zhang, Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425, 577–584 (2003).
  4. L. Strizzi, C. Bianco, N. Normanno, D. Salomon, Cripto-1: A multifunctional modulator during embryogenesis and oncogenesis. Oncogene 24, 5731–5741 (2005).
  5. J. S. Desgrosellier, N. A. Mundell, M. A. McDonnell, H. L. Moses, J. V. Barnett, Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev. Biol. 280, 201–210 (2005).
  6. H. Zhang, A. Bradley, Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122, 2977–2986 (1996).
  7. J. Massague, S. W. Blain, R. S. Lo, TGFβ signaling in growth control, cancer, and heritable disorders. Cell 103, 295–309 (2000).
  8. Y. Tang, V. Katuri, A. Dillner, B. Mishra, C. X. Deng, L. Mishra, Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice. Science 299, 574–577 (2003).
  9. J. Larsson, M. J. Goumans, L. J. Sjostrand, M. A. van Rooijen, D. Ward, P. Leveen, X. Xu, P. ten Dijke, C. L. Mummery, S. Karlsson, Abnormal angiogenesis but intact hematopoietic potential in TGF-β type I receptor-deficient mice. EMBO J. 20, 1663–1673 (2001).
  10. M. Oshima, H. Oshima, M. M. Taketo, TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev. Biol. 179, 297–302 (1996).
  11. B. Liu, Y. Sun, F. Jiang, S. Zhang, Y. Wu, Y. Lan, X. Yang, N. Mao, Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis. Blood 101, 124–133 (2003).

    12. Citation: K. Kitisin, T. Saha, T. Blake, N. Golestaneh, M. Deng, C. Kim, Y. Tang, K. Shetty, B. Mishra, L. Mishra, TGF-β signaling in development. Sci. STKE (Connections Map in Database of Cell Signaling, as seen July 2007) http://stke.sciencemag.org/cgi/cm/stkecm;CMP_18196.

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