Table 1. Specific examples of candidate genes that are "highly related" to human genes associated with genetic diseases [as curated from the Homophila Web site (1)]. The fly genes are listed together with the corresponding FlyBase genome annotations (FBgns) and the disease-related human orthologs or "highly related" genes, as well as the mutations that are associated with the specific diseases. More information about the diseases can be found at the Online Mendelian Inheritance in Man (OMIM) site (2). The human homologs are purely based on sequence homologies using strict criteria of E value < 10^–20 to identify potential homologs; hence, they are referred to as "highly related" genes. A few candidate gene homologs that have E values < 10^–10 are also listed, because they were independently identified as sequence homologs by reciprocal-best-blast (RBB). This is in accordance with Reiter et al. (3), in which sequence homologies of E < 10^–10 were considered highly related. [Reprinted with permission from (4).]

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*Corresponding author. E-mail, rtmoon{at}u.washington.edu

1. Homophila: Human Disease to Drosophila Gene Database, http://superfly.ucsd.edu/homophila/
2. OMIM (Online Mendelian Inheritance in Man), http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM
3. L. T. Reiter, L. Potocki, S. Chien, M. Gribskov, E. Bier, "A Systematic Analysis of Human Disease-Associated Gene Sequences in Drosophila melanogaster," Genome Research 11, 1114-1125 (Cold Spring Harbor Labratory Press, NY, 2001).
4. R. DasGupta, A. J. Kaykas, R. T. Moon, N. Perrimon, Functional genomic analysis of the Wnt/Wingless signaling pathway. Science 308, 826-833 (2005). (published online April 7 2005; 10.1126/science.1109374). [Abstract] [Full Text]

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Citation: R. T. Moon, Wnt/beta-catenin pathway. Sci. STKE (Connections Map, Human Diseases Table), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_5533.

© 2005 American Association for the Advancement of Science