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Animation 1. Phosphoinositide 3-Kinase Activation Stimulates Cell Survival and Proliferation.

Animation 2. Phosphoinositide 3-Kinase Activation Regulates Metabolism, the Cytoskeleton, and the Tec Family Kinases.

These animations were created by Cameron Slayden for Lewis C. Cantley and show some of the molecular events associated with growth factors activating receptor tyrosine kinases that lead to the stimulation of phosphoinositide 3-kinase (PI3K). In Animation 1, growth factors stimulate cell survival and entry into the S phase of the cell cycle. In Animation 2, growth factors stimulate the activation of proteins that regulate the cytoskeleton, stimulation of protein synthesis, and stimulation of the Tec family of tyrosine kinases. Animation 2 also shows how the action of phosphatases, such as PTEN, terminates signaling and resets the system to receive a new stimulus.

L. C. Cantley, Phosphoinositide 3-Kinase Pathway. (Connections Map),[Canonical Pathway]

Citation for these animations: L. C. Cantley, Animations of PI3K Signaling. Sci. STKE (Supplement to Connections Maps),;CMP_6557/DC1.

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882