Two schematic diagrams were prepared to show the organization of the signaling components involved in T cell signal transduction leading to regulation of gene expression. The first schematic was prepared by Dr. Koretzky's lab and the second was prepared by Science's STKE artist Julie White, with the scientific oversight of Andrew Singer and Gary Koretzky.
Schematic 1. The T cell receptor subunits and coreceptors are shown in the plasma membrane. Kinases and adaptors that contribute to this multimolecular signaling complex are shown. Signaling through phospholipase C is shown in orange and signaling through the Ras-mitogen-activated protein kinase (MAPK) cascade is shown in green.
Schematic 2. Signaling initiated by engagement of the T cell receptor (TCR). The formation of a multimolecular complex, nucleated by the adaptors SLP-76 and LAT, coordinates numerous second messenger cascades. The cellular response is also determined by the engagement of costimulatory receptors such as CD28. TCR signaling is regulated at multiple steps, and it is through the integration of these positive and negative regulators that T cells are driven toward proliferation, differentiation, or apoptosis. Adaptor proteins are shown in orange with organge labels and intracellularly, kinases are blue. The immunoreceptor tyrosine-based activation motifs are shown as black lines on the TCR, and the two phosphatase domains of CD45 are shown as red lines.
G. A. Koretzky, A. L. Singer, T cell signal transduction pathway. Sci. STKE (Connections Maps, as seen April 2003), http://stke.sciencemag.org/cgi/cm/CMP_7019. [Canonical Pathway]
Citation for these schematics: G. A. Koretzky, A. L. Singer, T cell signal transduction schematic. Sci. STKE (Supplement to Connections Maps), http://stke.sciencemag.org/cgi/content/full/sigtrans;CMP_7019/DC1.
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882