This schematic was prepared by D. V. Goeddel's laboratory. The diagram illustrates the signaling processes that are initiated by activation of the tumor necrosis factor (TNF) receptor (TNF-R1).
G. Chen, D. V. Goeddel, TNF Pathway. Science's STKE (Connections Maps, as seen May 2002), http://stke.sciencemag.org/cgi/cm/CMP_7107. [Canonical Pathway]
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882