This animation was created by Carin Cain for Curt M. Horvath and shows activation of the Jak-STAT pathway, specifically STAT1, in response to type I interferons, such as interferon a and interferon b. The animation shows that the phosphorylated STAT1 and STAT2 dimer interacts with a third transcriptional regulator IRF9 to stimulate gene expression.
D. Aaronson, C. M. Horvath, Type I Interferon a/b Pathway. (Connections Maps, as seen May 2002), http://stke.sciencemag.org/cgi/cm/CMP_8390 [Canonical Pathway]
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882