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Sci. STKE, 15 March 2005
[DOI: 10.1126/stke.2752005pe11]

Alone at Last! New Functions for Ca2+ Channel β Subunits?

(An Interactive Three-Dimensional View of the Calcium Channel β Subunit with the AID Domain of the {alpha} Subunit)

Matthieu Rousset, Thierry Cens, and Pierre Charnet*

Neurobiologie Moléculaire, CRBM FRE 2593, CNRS, 1919 Route de Mende, 34293 Montpellier Cedex, France.

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*Corresponding author. E-mail, pierre.charnet{at}crbm.cnrs.fr

Chime image. The β subunit of the voltage-gated calcium channel cocrystalized with the alpha-interacting domain (AID) of the pore-forming {alpha} subunit based on the PDB file 1T3L. The SH3 domain of the β subunit is blue and the guanylate kinase (GK) domain is dark pink. Unordered regions of the β subunit are not shown. The AID is green. The beta-interacting domain (BID) is part of the GK domain and is shown as wireframe in lighter pink. The image is a CHIME version of this structure, which can be manipulated and viewed from different perspectives. Click on the CHIME image to manipulate your view of the protein. Hold down and drag the left mouse button to rotate the molecule. Drag the mouse over the CHIME image with the "Shift" key depressed will allow you to increase or decrease molecule's size. Right-clicking anywhere on the CHIME image, or using either mouse button to click on the "MDL" in the lower right corner will generate a pop-up menu that will allow you to rotate the image, or to change the mode in which it is displayed.

Viewing this structure requires the CHIME plug-in, which can be downloaded from MDL.

Fig. 1. Static representation from Figure 1 of the full text. The SH3 domain of the β subunit is blue and the guanylate kinase (GK) domain is dark pink. Unordered regions of the β subunit are shown as dotted lines. The AID is green. The beta-interacting domain (BID) is part of the GK domain and is shown as wireframe.

Citation: M. Rousset, T. Cens, P. Charnet, Alone at last! New functions for Ca2+ channel β subunits? Sci. STKE 2005, pe11 (2005).


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