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Sci. Signal., 24 June 2008 REVIEWSDissociation of Heterotrimeric G Proteins in CellsDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912–2300, USA. Gloss: Heterotrimeric G proteins are among the most important and widely studied classes of signaling proteins. The long-standing model of G protein function includes physical dissociation of G *Corresponding author. E-mail: nlambert{at}mcg.edu
Citation: N. A. Lambert, Dissociation of Heterotrimeric G Proteins in Cells. Sci. Signal. 1, re5 (2008). The editors suggest the following Related Resources on Science sites:In Science Signaling
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subunits and Gβ
dimers as an essential prerequisite for signaling, even though physical dissociation had, until recently, only been observed by using isolated proteins in solution. Some recent studies have concluded that G protein dissociation does not occur in intact cells, whereas others have reported that dissociation does occur. This mini-review reconciles these points of view by emphasizing a model that includes an equilibrium between active heterotrimers and dissociated subunits. This model is consistent with all of the available experimental evidence. Attention then turns to a related question: Is heterotrimer dissociation necessary for signaling? The answer to this question is less clear and may be different for different signaling pathways.
Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
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