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Sci. Signal., 7 August 2012
Vol. 5, Issue 236, p. re4
The Abluminal Endothelial Membrane in Neurovascular Remodeling in Health and Disease
Dirk M. Hermann* and
Department of Neurology, University Hospital Essen, Hufelandstrasse 55, D-45122 Essen, Germany.
Gloss: The blood-brain barrier (BBB) can break down in response to brain injury, and stepwise restoration of its integrity occurs during subsequent neurovascular remodeling. In this Review, with 5 figures and 125 references, we outline the signaling processes at the abluminal endothelial membrane that contribute to the restitution of BBB integrity in the injured brain. A detailed understanding of these signaling events may yield new targets for pharmacological therapy of diseases associated with brain injury.