Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 26 February 2013
Vol. 6, Issue 264, p. re1
[DOI: 10.1126/scisignal.2003669]

REVIEWS

Nonredundant Functions for Ras GTPase-Activating Proteins in Tissue Homeostasis

Philip D. King*, Beth A. Lubeck, and Philip E. Lapinski

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA

Gloss: Many cell surface receptors trigger activation of the small guanosine triphosphate–binding protein Ras, conveying signals for cell proliferation, survival, and differentiation. However, excessive Ras activation results in uncontrolled tissue growth and susceptibility to diseases, such as cancer. Ras guanosine triphophatase (GTPase)–activating proteins (RasGAPs) inactivate Ras to maintain normal signaling activity. This Review, which has 2 figures, 2 tables, and 147 references, discusses the role of individual RasGAP family members in normal tissue and in disease.

* Corresponding author. E-mail: kingp{at}umich.edu

Citation: P. D. King, B. A. Lubeck, P. E. Lapinski, Nonredundant Functions for Ras GTPase-Activating Proteins in Tissue Homeostasis. Sci. Signal. 6, re1 (2013).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man.
P. E. Burrows, M. L. Gonzalez-Garay, J. C. Rasmussen, M. B. Aldrich, R. Guilliod, E. A. Maus, C. E. Fife, S. Kwon, P. E. Lapinski, P. D. King, et al. (2013)
PNAS 110, 8621-8626
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882