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Sci. Signal., 15 April 2008
Vol. 1, Issue 15, p. re2
[DOI: 10.1126/stke.115re2]


Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity?

Martin Lackmann1* and Andrew W. Boyd2

1Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
2Leukaemia Foundation Laboratory, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, 4029, Australia.

Gloss: Signaling by erythropoietin-producing hepatoma (Eph) receptors and cell-surface ephrin ligands modulates adhesive and morphological cell properties and thereby coordinates cell movement and positioning in normal and oncogenic development. Precise cell positioning relies not only on the accurately graded abundance of individual Eph-ephrin pairs but also on the sum of their interactions within particular tissue compartments and their modulation through crosstalk with a range of other signaling systems. In this Review, we discuss the salient features of Eph-ephrin biology and provide views into some of the seemingly confusing aspects that underlie Eph signaling during normal and oncogenic vertebrate development.

*Corresponding author. E-mail, martin.lackmann{at}

Citation: M. Lackmann, A. W. Boyd, Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity? Sci. Signal. 1, re2 (2008).

Eph/Ephrin signalling maintains eye field segregation from adjacent neural plate territories during forebrain morphogenesis.
F. Cavodeassi, K. Ivanovitch, and S. W. Wilson (2013)
Development 140, 4193-4202
   Abstract »    Full Text »    PDF »
Eph Receptor Signaling and Ephrins.
E. M. Lisabeth, G. Falivelli, and E. B. Pasquale (2013)
Cold Spring Harb Perspect Biol 5, a009159
   Abstract »    Full Text »    PDF »
Developing T-cell migration: role of semaphorins and ephrins.
D. A. Mendes-da-Cruz, M. A. Stimamiglio, J. J. Munoz, D. Alfaro, E. Terra-Granado, J. Garcia-Ceca, L. M. Alonso-Colmenar, W. Savino, and A. G. Zapata (2012)
FASEB J 26, 4390-4399
   Abstract »    Full Text »    PDF »
EphA2 Activation Promotes the Endothelial Cell Inflammatory Response: A Potential Role in Atherosclerosis.
S. D. Funk, A. Yurdagul Jr, P. Albert, J. G. Traylor Jr, L. Jin, J. Chen, and A. W. Orr (2012)
Arterioscler Thromb Vasc Biol 32, 686-695
   Abstract »    Full Text »    PDF »
EphA2/Ephrin-A1 Signaling Complexes Restrict Corneal Epithelial Cell Migration.
N. Kaplan, A. Fatima, H. Peng, P. J. Bryar, R. M. Lavker, and S. Getsios (2012)
Invest. Ophthalmol. Vis. Sci. 53, 936-945
   Abstract »    Full Text »    PDF »
Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors.
P. W. Janes, B. Griesshaber, L. Atapattu, E. Nievergall, L. L. Hii, A. Mensinga, C. Chheang, B. W. Day, A. W. Boyd, P. I. Bastiaens, et al. (2011)
J. Cell Biol. 195, 1033-1045
   Abstract »    Full Text »    PDF »
A Paradigm Shift in EPH Receptor Interaction: Biological Relevance of EPHB6 Interaction with EPHA2 and EPHB2 in Breast Carcinoma Cell Lines.
B. P. Fox and R. P. Kandpal (2011)
Cancer Genomics Proteomics 8, 185-193
   Abstract »    Full Text »    PDF »
PTP1B regulates Eph receptor function and trafficking.
E. Nievergall, P. W. Janes, C. Stegmayer, M. E. Vail, F. G. Haj, S. W. Teng, B. G. Neel, P. I. Bastiaens, and M. Lackmann (2010)
J. Cell Biol. 191, 1189-1203
   Abstract »    Full Text »    PDF »
Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries.
J. O. Bush and P. Soriano (2010)
Genes & Dev. 24, 2068-2080
   Abstract »    Full Text »    PDF »
Architecture of Eph receptor clusters.
J. P. Himanen, L. Yermekbayeva, P. W. Janes, J. R. Walker, K. Xu, L. Atapattu, K. R. Rajashankar, A. Mensinga, M. Lackmann, D. B. Nikolov, et al. (2010)
PNAS 107, 10860-10865
   Abstract »    Full Text »    PDF »
Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2.
K. Salaita, P. M. Nair, R. S. Petit, R. M. Neve, D. Das, J. W. Gray, and J. T. Groves (2010)
Science 327, 1380-1385
   Abstract »    Full Text »    PDF »
Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin-Expressing Cells.
C. Jorgensen, A. Sherman, G. I. Chen, A. Pasculescu, A. Poliakov, M. Hsiung, B. Larsen, D. G. Wilkinson, R. Linding, and T. Pawson (2009)
Science 326, 1502-1509
   Abstract »    Full Text »    PDF »
An All-Purpose Tool for Axon Guidance.
L. C. Schecterson and M. Bothwell (2008)
Science Signaling 1, pe50
   Abstract »    Full Text »    PDF »
Spatial Structure and pH-dependent Conformational Diversity of Dimeric Transmembrane Domain of the Receptor Tyrosine Kinase EphA1.
E. V. Bocharov, M. L. Mayzel, P. E. Volynsky, M. V. Goncharuk, Y. S. Ermolyuk, A. A. Schulga, E. O. Artemenko, R. G. Efremov, and A. S. Arseniev (2008)
J. Biol. Chem. 283, 29385-29395
   Abstract »    Full Text »    PDF »

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