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Sci. Signal., 15 July 2008 REVIEWSEthanols Molecular TargetsR. Adron Harris1*, James R. Trudell2, and S. John Mihic1
1Section of Neurobiology and Waggoner Center for Alcohol and Addiction Research, Institutes for Neuroscience and Cell & Molecular Biology, University of Texas, Austin, TX 78712, USA. Gloss: For much of the 20th century, it was widely believed that ethanol exerts its effects on neuronal function in a nonspecific manner—perhaps through the disordering of membrane lipids. However, over the past two decades, evidence has mounted that ethanol instead produces its effects by altering the functioning of specific proteins through its interaction with a select few amino acids in those proteins. In this Review with 2 figures and 60 citations, we focus on proteins for which evidence for specific alcohol binding sites has been obtained, and we briefly describe and compare these ethanol receptors. *Corresponding author. E-mail, harris{at}mail.utexas.edu
Citation: R. A. Harris, J. R. Trudell, S. J. Mihic, Ethanols Molecular Targets. Sci. Signal. 1, re7 (2008). The editors suggest the following Related Resources on Science sites:In Science Signaling
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882