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Sci. Signal., 8 September 2009
Vol. 2, Issue 87, p. re6
[DOI: 10.1126/scisignal.287re6]

REVIEWS

Oncogenic EGFR Signaling Networks in Glioma

Paul H. Huang1*, Alexander M. Xu2, and Forest M. White2,3

1 Protein Networks Team, Section of Cell and Molecular Biology, Institute of Cancer Research, London SW3 6JB, UK.
2 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Gloss: The epidermal growth factor receptor (EGFR) is a transmembrane protein that regulates many fundamental cellular processes, including growth, survival, and migration. EGFR is amplified, overexpressed, or mutated in various types of cancer, resulting in the deregulation of these critical cellular processes. In this Review, which has four figures and 120 citations, we examine the mechanisms by which EGFR contributes to oncogenic transformation in an aggressive form of brain tumor (glioblastoma) and discuss the limitations of current treatment strategies. Finally, we offer an outlook on how these therapies may be improved through the use of systems biology.

* Corresponding author. E-mail, paul.huang{at}icr.ac.uk

Citation: P. H. Huang, A. M. Xu, F. M. White, Oncogenic EGFR Signaling Networks in Glioma. Sci. Signal. 2, re6 (2009).


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