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Sci. STKE, 11 December 2001
Vol. 2001, Issue 112, p. re20
[DOI: 10.1126/stke.2001.112.re20]

REVIEWS

Signals from Eph and Ephrin Proteins: A Developmental Tool Kit

Andrew W. Boyd1* and Martin Lackmann2

1Leukaemia Foundation Laboratory, Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, 4029, Australia
2Epithelial Biology Laboratory, Ludwig Institute for Cancer Research (Melbourne Branch), P.O. Royal Melbourne Hospital, 3050, Australia.

Gloss: Interactions between Eph receptor family members and their ligands, the ephrins, are critical to many important embryonic patterning events. Evidence is emerging that also implies a role in pathological processes, including cancer and tissue injury. How do 14 Eph and nine ephrin proteins generate the great complexity of signaling mechanisms required to regulate cell movements as diverse as axon guidance, tissue boundary formation, and formation of the vasculature? We review how functional complexity is generated through modular usage of Eph and ephrin components, and discuss recent observations that highlight the unusual versatility of signaling mechanisms provided by this receptor-ligand system.

*Corresponding author. E-mail: andrewBo{at}qimr.edu.au

Citation: A. W. Boyd, M. Lackmann, Signals from Eph and Ephrin Proteins: A Developmental Tool Kit. Sci. STKE 2001, re20 (2001).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Specific and Shared Targets of Ephrin A Signaling in Epidermal Keratinocytes.
R. Walsh and M. Blumenberg (2011)
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Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity?.
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