Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 9 January 2001
Vol. 2001, Issue 64, p. re1
[DOI: 10.1126/stke.2001.64.re1]

REVIEWS

TGF-β Superfamily Signaling and Left-Right Asymmetry

Malcolm Whitman and Mark Mercola

The authors are in the Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. E-mail: mmercola{at}hms.harvard.edu (M.M.); malcolm_whitman{at}hms.harvard.edu (M.W.)

Gloss: The invariant left-right asymmetry of visceral organs in higher chordates depends on signal transduction initiated by the transforming growth factor-β (TGF-β) superfamily of secreted proteins during early embryogenesis. TGF-β proteins are well known for their roles in numerous other developmental processes, including the specification of dorsoventral pattern. This review discusses current knowledge of the regulatory hierarchies that ensure invariant left-right asymmetry as well as the potential mechanisms that permit a common set of signaling proteins to specify pattern along both the left-right and dorsoventral body axes.

Citation: M. Whitman, M. Mercola, TGF-β Superfamily Signaling and Left-Right Asymmetry. Sci. STKE 2001, re1 (2001).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A role for Vg1/Nodal signaling in specification of the intermediate mesoderm.
B. M. Fleming, R. Yelin, R. G. James, and T. M. Schultheiss (2013)
Development 140, 1819-1829
   Abstract »    Full Text »    PDF »
Neurula rotation determines left-right asymmetry in ascidian tadpole larvae.
K. Nishide, M. Mugitani, G. Kumano, and H. Nishida (2012)
Development 139, 1467-1475
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882