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Sci. STKE, 9 January 2001 REVIEWSTGF-ß Superfamily Signaling and Left-Right AsymmetryMalcolm Whitman, and Mark Mercola The authors are in the Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. E-mail: mmercola{at}hms.harvard.edu (M.M.); malcolm_whitman{at}hms.harvard.edu (M.W.) The invariant left-right asymmetry of visceral organs in higher chordates depends on signal transduction initiated by the transforming growth factor-ß (TGF-ß) superfamily of secreted proteins during early embryogenesis. TGF-ß proteins are well known for their roles in numerous other developmental processes, including the specification of dorsoventral pattern. This review discusses current knowledge of the regulatory hierarchies that ensure invariant left-right asymmetry as well as the potential mechanisms that permit a common set of signaling proteins to specify pattern along both the left-right and dorsoventral body axes. Citation: © 2001 American Association for the Advancement of Science
Citation: M. Whitman, M. Mercola, TGF-ß Superfamily Signaling and Left-Right Asymmetry. Sci. STKE 2001, re1 (2001). The editors suggest the following Related Resources on Science sites:In Science Signaling
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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
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