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Sci. STKE, 26 June 2001
Vol. 2001, Issue 88, p. re1
[DOI: 10.1126/stke.2001.88.re1]

REVIEWS

Cycling of Synaptic Vesicles: How Far? How Fast!

Thierry Galli and Volker Haucke

T. Galli is in the Membrane Traffic and Neuronal Plasticity Group, INSERM U536, Institut du Fer-à-moulin, 75005 Paris, France. E-mail: thierry.galli{at}curie.fr
V. Haucke is in the Zentrum Biochemie & Molekulare Zellbiologie, University of Göttingen, D-37073 Göttingen, Germany. E-mail: vhaucke{at}gwdg.de

Gloss: Synaptic vesicles are the major secretory organelles within the nervous system that store and secrete nonpeptide neurotransmitters. Upon electrical stimulation and the consequent influx of calcium into the presynaptic nerve terminal, a fraction of the synaptic vesicles fuses with the plasma membrane and releases its neurotransmitter content into the synaptic cleft. Because the nerve terminal can be far away from the protein synthesis machinery, which is located in the somatodendritic part of a neuron, synaptic vesicles are regenerated locally by recycling. Physiological experiments indicate that in addition to the well-established slow mode for the cycling of vesicles, many synapses have the capacity to regenerate fusion-competent synaptic vesicles by a much faster pathway within seconds. Although the same fusion machinery appears to be utilized by both the fast and slow tracks of vesicle cycling, a number of unique components are involved in the slow reformation of synaptic vesicles by clathrin-mediated endocytosis. We describe here the unique and the shared components of each track and attempt to identify common mechanisms that could serve as a link between these pathways.

Citation: T. Galli, V. Haucke, Cycling of Synaptic Vesicles: How Far? How Fast! Sci. STKE 2001, re1 (2001).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In Vivo Imaging of Intersynaptic Vesicle Exchange Using VGLUT1Venus Knock-In Mice.
E. Herzog, F. Nadrigny, K. Silm, C. Biesemann, I. Helling, T. Bersot, H. Steffens, R. Schwartzmann, U. V. Nagerl, S. El Mestikawy, et al. (2011)
J. Neurosci. 31, 15544-15559
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