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Sci. STKE, 4 September 2001
Vol. 2001, Issue 98, p. re1
[DOI: 10.1126/scisignal.982001re1]

REVIEWS

Fungal Histidine Kinases

Jennifer L. Santos and Kazuhiro Shiozaki

The authors are in the Biochemistry and Molecular Biology Graduate Program, University of California, Davis. K. Shiozaki is also in the Section of Microbiology, University of California, Davis, CA 95616, USA. E-mail: kshiozaki{at}ucdavis.edu

Gloss: Unicellular organisms and cells in higher life forms have signaling pathways by which environmental stimuli are transmitted to cellular machineries that modulate metabolism and mode of growth. Signals are often propagated by the transient phosphorylation of proteins that constitute such intracellular pathways. Like many bacteria, yeast species have cellular pathways in which signaling is achieved by relaying a phosphoryl group from histidine to aspartate residues of proteins. We will discuss recent studies of the "phosphorelay" signaling systems in yeasts and their potential as targets for novel antibiotics.

Citation: J. L. Santos, K. Shiozaki, Fungal Histidine Kinases. Sci. STKE 2001, re1 (2001).

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